December 5, 2023

University of Kentucky Studying Relationship Between Variations of the APOE Gene and Metabolism

The University of Kentucky Medical Center is conducting a study wherein they test metabolic rate at rest and during a cognitive challenge in healthy adults. The results of this study may help investigators identify new targets for the prevention and treatment of cognitive decline and dementia.

Impaired metabolism and APOE genotype are independent risk factors for cognitive impairment and dementia. In this study researchers will test whether the different versions of APOE have varying effects on whole body and brain metabolism.

Researchers will measure participants’ metabolic rates while resting and during a computer-based cognitive challenge using a technique called indirect calorimetry that measures oxygen intake and carbon dioxide output through a loose-fitting face mask. Participants will also be asked to provide blood samples for genetic testing of APOE genotype and two urine samples to measure carbohydrates, fats, and proteins the body is metabolizing.

Find out whether you or your loved one is eligible for the trial.

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